Understanding how a specific protein affects immune cells to fight lung infections
Official title: Mechanisms of GM-CSF-mediated metabolic regulation of monocyte function for control of pulmonary infection
Funded at Case Western Reserve University · NIH-10899617 · Data updated 2026-11-12
This study is looking at how a substance called GM-CSF helps certain immune cells fight off lung infections like pneumonia, with the hope that what we learn could lead to better treatments for patients dealing with these infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | August 5, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL153758-04 |
| Project ID | NIH-10899617 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of recurrent pneumonia or other pulmonary infections.
✕Less likely to help
Patients with non-infectious lung conditions or those who do not have a history of pulmonary infections may not benefit from this research.
What this research studies
This research investigates the role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in regulating immune cells called Ly6Chi monocytes, which are crucial for controlling lung infections like pneumonia. The study aims to uncover how GM-CSF influences the metabolism and function of these immune cells in the presence of bacterial infections. By examining the local environment and cytokine interactions, the research seeks to identify mechanisms that enhance the immune response against pathogens. Patients may benefit from insights that could lead to new treatments for pneumonia and other pulmonary infections.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for pneumonia and enhance the body's ability to fight lung infections.
How similar studies have gone: Previous research has shown promising results in understanding immune cell functions and their metabolic regulation, suggesting potential for success in this area.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Liu, Xin — Case Western Reserve University
- Study coordinator: Liu, Xin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.