Understanding how a specific protein affects heart rhythm problems
Official title: Novel Roles of Protein phosphatase 2A in Cardiac Arrhythmia
Funded at Ohio State University · NIH-10943347 · Data updated 2026-11-12
This study is looking at a protein called B56α to see how it affects heart cell activity and sodium channels that help control heart rhythm, with the hope of finding new ways to help people with irregular heartbeats and reduce the risk of sudden cardiac issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $635,106 |
| NIH project number | 1R01HL175380-01 |
| Project ID | NIH-10943347 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of cardiac arrhythmias or those at high risk for sudden cardiac death.
✕Less likely to help
Patients with stable heart conditions that do not involve arrhythmias may not benefit from this research.
What this research studies
This research investigates the role of a protein called B56α in regulating heart cell activity, particularly focusing on how it influences sodium channels that are crucial for heart rhythm. By examining how this protein interacts with other components in heart cells, the research aims to uncover new pathways that could be targeted to prevent dangerous heart rhythms and sudden cardiac death. The approach includes both laboratory experiments and analysis of heart cell behavior under different conditions, particularly when the heart is under stress from adrenergic stimulation. The ultimate goal is to find new therapeutic strategies for patients suffering from arrhythmias.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the risk of life-threatening heart rhythm disorders.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways for heart rhythm regulation, indicating potential for success in this novel approach.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: El Refaey, Mona — Ohio State University
- Study coordinator: El Refaey, Mona
Related research
Other NIH-funded projects on the same topics.
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Precision imaging of heart rhythms to map arrhythmias without surgery
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New roles for a heart protein in preventing dangerous rhythms
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Understanding how small potassium channels affect heart rhythm and disease
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3D ultrasound mapping to locate sources of abnormal heart rhythms
This project uses a fast, radiation-free 3D ultrasound method to find where irregular heartbeats start in adults with arrhythmias.
-
Understanding a New Way to Control Heart Rhythm Problems
This work explores how a specific protein in the heart helps regulate electrical signals, aiming to find new ways to prevent dangerous heart rhythm issues.
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Exploring the mechanisms behind heart rhythm disorders
This conference is all about helping doctors and researchers understand what causes irregular heartbeats, so they can find better ways to diagnose and treat these issues for people at risk of serious health problems like strokes or sudden heart failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.