Understanding how a specific protein affects heart rhythm problems
Novel Roles of Protein phosphatase 2A in Cardiac Arrhythmia
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-10943347
This study is looking at a protein called B56α to see how it affects heart cell activity and sodium channels that help control heart rhythm, with the hope of finding new ways to help people with irregular heartbeats and reduce the risk of sudden cardiac issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10943347 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called B56α in regulating heart cell activity, particularly focusing on how it influences sodium channels that are crucial for heart rhythm. By examining how this protein interacts with other components in heart cells, the research aims to uncover new pathways that could be targeted to prevent dangerous heart rhythms and sudden cardiac death. The approach includes both laboratory experiments and analysis of heart cell behavior under different conditions, particularly when the heart is under stress from adrenergic stimulation. The ultimate goal is to find new therapeutic strategies for patients suffering from arrhythmias.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of cardiac arrhythmias or those at high risk for sudden cardiac death.
Not a fit: Patients with stable heart conditions that do not involve arrhythmias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the risk of life-threatening heart rhythm disorders.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways for heart rhythm regulation, indicating potential for success in this novel approach.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EL REFAEY, MONA — OHIO STATE UNIVERSITY
- Study coordinator: EL REFAEY, MONA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.