Understanding how a specific protein affects heart remodeling in response to high blood pressure
Official title: Integrative role of Rps6kb1 in pathological cardiac remodeling
Funded at Beckman Research Institute/city of Hope · NIH-11124862 · Data updated 2026-11-12
This study is looking at how a specific protein affects heart failure, especially in people with high blood pressure, to find new ways to help treat heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | July 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $761,883 |
| NIH project number | 5R01HL171309-02 |
| Project ID | NIH-11124862 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with hypertension or those at risk of developing heart failure.
✕Less likely to help
Patients without hypertension or existing heart conditions may not benefit from this research.
What this research studies
This research investigates the role of the Rps6kb1 protein in the development of heart failure, particularly how it influences the heart's response to high blood pressure. By studying heart muscle cells, the researchers aim to uncover the mechanisms that lead to pathological changes in the heart, transitioning from a healthy adaptive response to heart failure. The approach includes advanced techniques to analyze protein signaling pathways, which may reveal new therapeutic targets for preventing heart failure. Patients may benefit from insights that could lead to innovative treatments for heart conditions related to hypertension.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or treat heart failure in patients with high blood pressure.
How similar studies have gone: Previous research has shown promising results in understanding protein signaling in heart conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Wang, Zhao — Beckman Research Institute/city of Hope
- Study coordinator: Wang, Zhao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.