Understanding how a specific protein affects heart infections caused by viruses
Mechanistic characterization of a new master regulator of cardiac virus infections
This study is looking at how a protein called BEX1 affects the heart's reaction to viral infections, which can sometimes lead to heart failure, to help find new ways to treat these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10672435 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called BEX1 in the heart's response to viral infections, which can lead to heart failure. The study aims to understand how BEX1 influences inflammation in the heart during viral infections, as inflammation is crucial for fighting off viruses but can also cause damage if excessive. Researchers will explore BEX1's effects on viral infections in living organisms and its role in regulating antiviral responses in heart cells. By uncovering these mechanisms, the research seeks to identify potential therapeutic targets for treating cardiac viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart conditions related to viral infections.
Not a fit: Patients with heart conditions not related to viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart failure caused by viral infections.
How similar studies have performed: Other research has shown promise in understanding the role of inflammation in viral infections, making this approach a potentially valuable avenue for further exploration.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Yount, Jacob — Ohio State University
- Study coordinator: Yount, Jacob
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.