Understanding how a specific protein affects heart function in atrial fibrillation
Myosin Light Chain Dephosphorylation by PPP1R12C Promotes Atrial Hypocontractility and Atrial Fibrillation
This study is looking at how a protein called PPP1R12C affects heart muscle function in people with atrial fibrillation, with the goal of finding new ways to help improve heart performance and lower the risk of strokes for those living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10819480 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called PPP1R12C in regulating heart muscle function, particularly in patients with atrial fibrillation (AF). It aims to uncover how this protein influences the phosphorylation of myosin light chain, which is crucial for heart muscle contraction. By studying both human patients and mouse models, the research seeks to clarify the mechanisms that lead to reduced heart contractility and increased stroke risk in AF. The findings could lead to new therapeutic strategies to improve heart function and reduce stroke risk in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with atrial fibrillation who may be experiencing reduced heart contractility.
Not a fit: Patients without atrial fibrillation or those with other unrelated heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart function and lower the risk of stroke for patients with atrial fibrillation.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of atrial fibrillation, but this specific approach focusing on PPP1R12C is relatively novel.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Mccauley, Mark D — University of Illinois at Chicago
- Study coordinator: Mccauley, Mark D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.