Understanding how a specific protein affects heart cell recovery after injury
Official title: Investigating the role of SPRR1A in border zone cardiomyocytes during neonatal cardiac repair
Funded at University of Rochester · NIH-10994201 · Data updated 2026-11-12
This study is looking at a special protein in heart cells that are near damaged areas after a heart attack to see how they help heal and grow, especially in young hearts, which could lead to better ways to repair adult hearts.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 1F32HL175913-01 |
| Project ID | NIH-10994201 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have experienced a myocardial infarction and are interested in potential new treatment options.
✕Less likely to help
Patients who have not had a heart attack or those with advanced heart failure may not benefit from this research.
What this research studies
This research investigates the role of a protein called SPRR1A in heart cells that are located near damaged areas after a heart attack. The study focuses on how these border zone cardiomyocytes respond to injury and whether they can promote healing and regeneration, especially in neonatal hearts. By using advanced techniques like RNA-Sequencing and spatial transcriptomics, researchers aim to uncover the mechanisms that allow some heart cells to survive and proliferate while others do not. This could lead to new insights into improving heart repair processes in adults.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance heart repair and reduce complications after heart attacks.
How similar studies have gone: Other research has shown promising results in understanding cardiac regeneration, but the specific role of SPRR1A in this context is still being explored.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Zuppo, Daniel Anthony — University of Rochester
- Study coordinator: Zuppo, Daniel Anthony
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.