Understanding how a specific protein affects heart cell growth and function
Investigating the Role of MYH14 in Tension-Dependent Cardiomyocyte Hypertrophy
This study is looking at a protein called MYH14 in heart cells to see how it helps the heart grow stronger when it's under stress, which could lead to new ways to keep hearts healthy and prevent heart failure.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10677677 on NIH RePORTER |
What this research studies
This research investigates the role of the MYH14 protein in heart cells, particularly how it influences heart muscle growth in response to stress. Using genetically modified mice, the study aims to uncover the mechanisms by which MYH14 contributes to maintaining heart health and preventing heart failure. The researchers will analyze the protein's behavior in heart tissue and its interactions with other cellular components to better understand its function. This work could lead to new insights into heart disease and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of heart disease or those experiencing early signs of heart failure.
Not a fit: Patients with heart failure due to non-genetic factors or those who do not have a genetic predisposition to heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart failure, improving outcomes for patients with this condition.
How similar studies have performed: Previous research has shown that targeting specific proteins involved in heart function can lead to significant advancements in understanding and treating heart disease.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Wang, Jessica J — University of California Los Angeles
- Study coordinator: Wang, Jessica J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.