Understanding how a specific protein affects heart cell function and development
Official title: The roles of Fragile-X related protein 1 in cardiomyocyte and heart biology
Funded at Univ of North Carolina Chapel Hill · NIH-10996342 · Data updated 2026-11-12
This study is looking at how a specific protein affects heart cells, which are important for keeping your heart pumping, and it aims to understand how these cells change during heart development, with the hope that the findings could help improve heart health and treatments for heart-related issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $41,627 |
| NIH project number | 1F31HL176049-01 |
| Project ID | NIH-10996342 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with congenital heart conditions or those affected by genetic disorders related to heart function.
✕Less likely to help
Patients with heart conditions not linked to genetic factors or those over 21 years old may not benefit from this research.
What this research studies
This research investigates the role of Fragile-X related protein 1 in heart cells, specifically cardiomyocytes, which are crucial for pumping blood. The study focuses on how these cells adapt to changes in their environment during heart development, particularly through a process called alternative splicing that allows for the production of different protein forms. By using advanced techniques like CRISPR, the research aims to uncover the molecular mechanisms that regulate heart cell function and how disruptions in these processes can lead to heart-related conditions. Patients may benefit from insights gained about heart health and potential treatments for related disorders.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart conditions linked to genetic factors.
How similar studies have gone: Previous research has shown promising results in understanding the role of alternative splicing in heart biology, indicating that this approach has potential for success.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Bais, Gabrielle — Univ of North Carolina Chapel Hill
- Study coordinator: Bais, Gabrielle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.