Understanding how a specific protein affects heart cell behavior after injury
Novel role for the spectrin cytoskeleton in regulation of cardiac fibroblast activity, long-range communication and injury-induced fibrosis
This study is looking at how certain proteins in heart cells help the heart heal after a heart attack, with the goal of finding ways to improve recovery and prevent problems like irregular heartbeats.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10993685 on NIH RePORTER |
What this research studies
This research investigates the role of spectrin proteins in cardiac fibroblasts, which are crucial for heart repair after a heart attack. It aims to understand how these proteins influence the behavior of heart cells during the healing process, particularly how they regulate cell signaling and communication. By studying the dynamic responses of cardiac fibroblasts to injury, the research seeks to uncover the molecular pathways that lead to either healthy healing or pathological fibrosis. This could lead to new insights into preventing complications like arrhythmias and heart dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a myocardial infarction and are at risk for cardiac dysfunction or arrhythmias.
Not a fit: Patients with non-cardiac conditions or those who have not experienced a heart attack may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart attack patients by enhancing the healing process and reducing the risk of complications.
How similar studies have performed: Previous research has shown promising results in understanding cardiac fibroblast behavior, but the specific role of spectrin proteins in this context is still being explored.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Hund, Thomas Jeffrey — Ohio State University
- Study coordinator: Hund, Thomas Jeffrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.