Understanding how a specific protein affects glioblastoma cells
Official title: Determining the Mechanisms of RING1- and YY1-binding protein (RYBP) function and dysregulation in glioblastoma cells
Funded at Winthrop University · NIH-10936126 · Data updated 2026-11-12
This study is looking at a protein called RYBP to see how it helps fight glioblastoma, a tough type of brain cancer, and why it’s often less active in patients; by understanding this, researchers hope to find new ways to treat the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Winthrop University NIH-funded |
| Lab location | 1 site (Rock Hill, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $192,456 |
| NIH project number | 1R16NS141721-01 |
| Project ID | NIH-10936126 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma who may benefit from new therapeutic strategies targeting RYBP.
✕Less likely to help
Patients with other types of brain tumors or those not diagnosed with glioblastoma may not receive benefits from this research.
What this research studies
This research investigates the role of the RING1- and YY1-binding protein (RYBP) in glioblastoma, a highly aggressive brain tumor. The study aims to uncover how RYBP functions as a tumor suppressor and why its expression is often reduced in glioblastoma patients. Researchers will use advanced techniques to manipulate RYBP levels in glioblastoma cells and analyze the resulting changes in cell behavior, such as growth and movement. By identifying the genes regulated by RYBP, the research hopes to pave the way for new targeted therapies for glioblastoma.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, potentially improving patient survival rates.
How similar studies have gone: While the specific role of RYBP in glioblastoma is still being explored, similar approaches targeting gene regulation in cancer have shown promise in other studies.
Where this research is happening
-
Winthrop University
Rock Hill, United States Active
Researchers
- Principal investigator: Stovall, Daniel Brooks — Winthrop University
- Study coordinator: Stovall, Daniel Brooks
Related research
Other NIH-funded projects on the same topics.
-
Small molecules to block Slit2/ROBO in glioblastoma
A study to test small molecule drugs that block Slit2/ROBO signals to help treat glioblastoma in patients.
-
Immunotherapy for glioblastoma: advancing treatment and understanding
A patient-friendly summary of a grant exploring new immune-based treatments for glioblastoma to improve options for people affected by this brain cancer.
-
Small-molecule and biologic treatments for glioblastoma using targeted brain delivery
A new approach aims to use FPS-ZM1 to shrink brain swelling and support immunotherapy for glioblastoma, potentially helping patients recover after surgery.
-
Targeted therapies for glioblastoma in adults and kids
A large NIH program is exploring new brain cancer therapies, including drugs that reach the brain and work against glioblastoma in both children and adults.
-
6-thio-2'-deoxyguanosine for glioblastoma: a new approach to target tumors before surgery
A trial tests a novel drug given before glioblastoma surgery to see how it behaves in the body and within the tumor, and to learn how it affects cancer cells and the immune environment.
-
CD38-Driven Changes in Brain Tumor Metabolism and Immunity in Glioblastoma
A patient-facing look at how scientists plan to study how glioblastoma grows by changing its metabolism and dampening the immune response, with potential targets to help treatment in the future.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.