Understanding how a specific protein affects GABA levels in cells
Official title: Investigating the Role of SLC45A4 in GABA Metabolism
Funded at Rutgers Biomedical and Health Sciences · NIH-11014061 · Data updated 2026-11-12
This study is looking at how a protein called SLC45A4 affects a molecule called GABA, which plays an important role in how cancer cells grow and move, and it aims to help us understand how this could improve cancer treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $289,665 |
| NIH project number | 5R01GM149664-03 |
| Project ID | NIH-11014061 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers where GABA metabolism may play a significant role.
✕Less likely to help
Patients with conditions unrelated to GABA metabolism or those not diagnosed with cancer may not benefit from this research.
What this research studies
This research investigates the role of the SLC45A4 protein in regulating GABA, a key molecule involved in cell functions such as growth and migration. By analyzing data from various biological sources, the researchers aim to uncover how this protein influences GABA metabolism, particularly in cancer cells. The study employs advanced techniques to trace the movement of isotopes in cells, providing insights into the biochemical pathways involved. Patients may benefit from a better understanding of how GABA metabolism affects cancer progression and treatment.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting GABA metabolism in cancer treatment.
How similar studies have gone: Previous research has shown success in understanding the roles of other SLC transporters in disease, suggesting potential for this approach.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Su, Xiaoyang — Rutgers Biomedical and Health Sciences
- Study coordinator: Su, Xiaoyang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.