Understanding how a specific protein affects fertility in ovarian cells
Official title: Investigating the Mechanisms of Fertility Regulation by Salt-Inducible Kinase 3 in OvarianGranulosa Cells
Funded at University of Illinois at Chicago · NIH-11163033 · Data updated 2026-11-12
This study is looking at how a protein called SIK3 affects the cells that help with egg development in the ovaries, which is important for fertility, and it hopes to find new ways to help women who have trouble getting pregnant.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | May 16, 2025 |
| Project end | May 15, 2027 |
| Funding year | 2025 |
| Award (this year) | $53,974 |
| NIH project number | 1F30HD115294-01A1 |
| Project ID | NIH-11163033 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women facing difficulties in conceiving, particularly those with ovulatory disorders.
✕Less likely to help
Patients who do not have ovulatory dysfunction or those with infertility due to other causes may not benefit from this research.
What this research studies
This research investigates the role of salt-inducible kinase 3 (SIK3) in ovarian granulosa cells, which are crucial for fertility. By studying how SIK3 influences cell differentiation and metabolism in response to hormonal signals, the research aims to uncover the mechanisms behind ovulatory dysfunction. The approach involves using mouse models to observe changes in fertility when SIK3 is altered, providing insights into potential treatments for infertility. Patients may benefit from a better understanding of fertility issues and new therapeutic strategies based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for women experiencing infertility due to ovulatory dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding fertility mechanisms, but this specific investigation into SIK3 is novel.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Hayes, Emily Taylor — University of Illinois at Chicago
- Study coordinator: Hayes, Emily Taylor
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.