Understanding how a specific protein affects eye cell health and vision loss
Regulation of RPE degeneration by REV-ERBalpha
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-10667553
This study is looking at how a protein called REV-ERBα affects the health of eye cells that are important for vision, especially in conditions like age-related macular degeneration and retinitis pigmentosa, to find new ways to protect and restore these cells and help preserve your sight.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10667553 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called REV-ERBα in the health of retinal pigment epithelium (RPE) cells, which are crucial for vision. The study aims to understand how oxidative stress contributes to RPE degeneration, a key factor in conditions like age-related macular degeneration and retinitis pigmentosa. By exploring the molecular mechanisms that regulate RPE cell survival, the research seeks to identify new targets for therapies that could protect and rejuvenate these cells, potentially preserving vision. Patients may benefit from insights that could lead to innovative treatments for vision loss.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing vision loss due to age-related macular degeneration or retinitis pigmentosa.
Not a fit: Patients with vision loss due to causes unrelated to RPE degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that protect against vision loss in patients with age-related macular degeneration and retinitis pigmentosa.
How similar studies have performed: Previous research has shown promise in targeting oxidative stress and cellular mechanisms to improve eye health, indicating potential for success in this area.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, JING — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: CHEN, JING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute disease/disorder, acute disorder, Acute Disease