Understanding how a specific protein affects early pregnancy and placentation.
Hippo Signaling Effector and Placentation
This study is looking at how a protein called TEAD4 helps certain cells that are important for pregnancy grow and develop, which could help us understand why some women experience repeated pregnancy loss and find ways to improve their chances of a healthy pregnancy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-10800770 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called TEAD4 in the development of trophoblast progenitors, which are essential for successful embryo implantation and placentation. By using mutant mouse models, the study aims to uncover the molecular mechanisms that regulate the self-renewal and differentiation of these progenitor cells during early pregnancy. The research also seeks to explore the connection between these mechanisms and recurrent pregnancy loss, providing insights that could lead to improved outcomes for pregnancies affected by complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing recurrent pregnancy loss or complications related to early pregnancy.
Not a fit: Patients who are not currently experiencing pregnancy loss or related complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for early pregnancy loss and related complications.
How similar studies have performed: Other research has shown promise in understanding the role of molecular mechanisms in pregnancy outcomes, making this approach both relevant and potentially impactful.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Paul, Soumen — University of Kansas Medical Center
- Study coordinator: Paul, Soumen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.