Understanding how a specific protein affects colorectal cancer in African Americans
Inactivation of MSH3 in Colorectal Cancer and Race
This study is looking at how a protein called MSH3 works in repairing DNA and how problems with it, especially due to inflammation, can lead to higher rates of colorectal cancer in African American patients, with the goal of understanding why this group faces more challenges with the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10897946 on NIH RePORTER |
What this research studies
This research investigates the role of the MSH3 protein in colorectal cancer (CRC), particularly focusing on how its dysfunction, influenced by inflammation, affects African American patients. The study aims to understand how MSH3 normally repairs DNA and how its loss of function leads to increased cancer risk and poorer outcomes in this population. By analyzing genetic mutations and their impact on cancer progression, the research seeks to uncover critical insights into the disparities in CRC incidence and mortality among different racial groups. Patients may be involved in providing samples or data to help elucidate these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include African American individuals diagnosed with colorectal cancer.
Not a fit: Patients who do not have colorectal cancer or belong to other racial groups may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for colorectal cancer in African American patients.
How similar studies have performed: Previous research has shown that understanding genetic factors in cancer can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Carethers, John M — University of California, San Diego
- Study coordinator: Carethers, John M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.