Understanding how a specific protein affects cell death in Alzheimer's disease
Uncovering novel mechanisms of the CELF/Bruno protein ETR-1 in apoptosis
This study is looking at how a protein called ETR-1 affects the natural process of cell death, which is important for keeping our cells healthy, and it's using tiny worms to learn more about how this might help us understand and possibly prevent too much cell death in people with Alzheimer's disease.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Howard University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10515071 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called ETR-1 in the process of programmed cell death, known as apoptosis, which is crucial for maintaining healthy cellular function. By using a model organism, C. elegans, researchers can observe how ETR-1 influences apoptosis in real-time, particularly in the context of neurodegenerative diseases like Alzheimer's. The study aims to uncover the mechanisms by which ETR-1 regulates cell death, which could lead to new insights into how to prevent excessive cell death in Alzheimer's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or related neurodegenerative conditions.
Not a fit: Patients with non-neurodegenerative conditions or those not affected by Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating Alzheimer's disease by targeting the mechanisms of cell death.
How similar studies have performed: Other research has shown promising results in understanding apoptosis mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Washington, United States
- Howard University — Washington, United States (Active)
Researchers
- Principal investigator: Robinson, Courtney — Howard University
- Study coordinator: Robinson, Courtney
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.