Understanding how a specific protein affects brain signaling and memory processes
Mechanisms of cell adhesion molecule LRRTM2 in basal and potentiated synaptic signaling
This study is looking at how a protein called LRRTM2 helps control important brain receptors that affect learning and memory, and it could help us find new ways to treat cognitive disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10910131 on NIH RePORTER |
What this research studies
This research investigates the role of the LRRTM2 protein in regulating the positioning and function of AMPA receptors in the brain, which are crucial for learning and memory. By examining how LRRTM2 influences synaptic strength and plasticity, the study aims to uncover the mechanisms that govern neurotransmission at glutamatergic synapses. The approach involves acute disruption of LRRTM2 to observe its effects on synaptic signaling, providing insights into the molecular architecture of synapses. This research could lead to a better understanding of cognitive processes and potential therapeutic targets for cognitive disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cognitive impairments or those at risk for conditions affecting learning and memory.
Not a fit: Patients with conditions unrelated to cognitive function or those not experiencing memory issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cognitive functions and lead to new treatments for memory-related disorders.
How similar studies have performed: Previous research has shown promising results in understanding synaptic mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Pollitt, Stephanie Lynn — University of Maryland Baltimore
- Study coordinator: Pollitt, Stephanie Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.