Understanding how a specific protein affects brain function and learning
Mechanism of Par1c-mediated AMPA receptor trafficking and synaptic plasticity
['FUNDING_FELLOWSHIP'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-11165617
This study is looking at how a protein called Par1c affects the movement of important receptors in the brain that help with learning and memory, using specially modified mice to see how changes in Par1c might impact thinking and connections between brain cells, which could help us understand conditions like autism and bipolar disorder better.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-11165617 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the Par1c protein in the trafficking of AMPA receptors, which are crucial for synaptic plasticity and learning in the brain. By studying genetically modified mice, the researchers aim to uncover how changes in Par1c levels influence cognitive functions and the formation of synaptic connections. The study focuses on understanding the mechanisms behind long-term potentiation, a process that enhances communication between neurons, which is vital for learning and memory. Insights gained from this research could lead to better understanding of conditions like autism spectrum disorder and bipolar disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or bipolar disorder, particularly those with genetic variations related to the Par1c protein.
Not a fit: Patients without autism spectrum disorder or bipolar disorder, or those not exhibiting related cognitive impairments, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights into the biological mechanisms underlying cognitive disorders, potentially leading to improved treatments.
How similar studies have performed: Previous research has shown promising results in understanding synaptic plasticity and its relation to cognitive disorders, indicating that this approach has potential for success.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHEAR, REBECCA — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: SHEAR, REBECCA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder, autism spectrum disorder, Autistic Disorder, autistic spectrum disorder