Understanding how a specific protein affects brain development and autism
The Contribution of Microglial MEF2C to Brain Development
This study is looking at how a protein called MEF2C affects brain development and the health of brain cells, which could help us understand and find new treatments for conditions like autism and intellectual disabilities.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11002639 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called MEF2C in the development of the brain, particularly focusing on its impact on microglial cells, which are crucial for brain health. The study aims to understand how changes in MEF2C can lead to neurodevelopmental disorders like autism and intellectual disabilities. By using advanced laboratory techniques, researchers will explore how MEF2C influences brain cell behavior and connections during critical developmental periods. This research could provide insights into potential new treatments for these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include children under 11 years old who are diagnosed with autism spectrum disorder or related intellectual disabilities.
Not a fit: Patients who are older than 11 years or do not have autism spectrum disorder or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating autism and related neurodevelopmental disorders.
How similar studies have performed: While the specific role of microglial MEF2C in autism is being explored for the first time, there is growing evidence that microglial function is critical in neurodevelopmental disorders.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Coufal, Nicole Gabriele — University of California, San Diego
- Study coordinator: Coufal, Nicole Gabriele
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.