Understanding how a specific protein affects brain damage after cardiac arrest
Kinase regulation in cerebral ischemia
['FUNDING_R01'] · UNIVERSITY OF SOUTH FLORIDA · NIH-11326878
This study is looking at a protein called SGK1 to see how it affects brain injuries from cardiac arrest, and it hopes to find ways to improve brain health and function for people who have gone through this experience.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTH FLORIDA (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-11326878 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called SGK1 in brain injuries caused by cardiac arrest. It aims to understand how SGK1 contributes to decreased blood flow and inflammation in the brain, which can lead to cell death and cognitive deficits. Using advanced imaging techniques, the study will explore the effects of inhibiting SGK1 in animal models to determine if this can improve brain health and function after such injuries. The findings could provide insights into new therapeutic strategies for patients who have experienced cardiac arrest.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced cardiac arrest and are at risk for brain injuries.
Not a fit: Patients who have not experienced cardiac arrest or have other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve recovery and outcomes for patients who suffer from cardiac arrest.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways for improving outcomes in brain injuries, suggesting that this approach could be effective.
Where this research is happening
TAMPA, UNITED STATES
- UNIVERSITY OF SOUTH FLORIDA — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, REGGIE HUI-CHAO — UNIVERSITY OF SOUTH FLORIDA
- Study coordinator: LEE, REGGIE HUI-CHAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury