Understanding how a specific protein affects body position sensing
The encoding of proprioceptive signaling by Nav1.6
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11086574
This study is looking at how a specific protein helps our body know where it is and how it's moving, which is important for coordination and movement, and it's for anyone interested in understanding more about how our senses work and how they might be affected in movement-related conditions.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11086574 on ClinicalTrials.gov |
What this research studies
This research aims to explore the molecular mechanisms involved in proprioception, which is the body's ability to sense its position and movement. By focusing on a protein called Nav1.6, the study will investigate how it influences sensory neurons responsible for proprioceptive signaling. The researchers will use advanced genetic techniques, including CRISPR/Cas9, to manipulate genes in these sensory neurons, allowing them to better understand how proprioception works and its impact on motor behaviors. This could lead to insights into conditions that affect movement and coordination.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting proprioception or motor coordination, such as autism spectrum disorder.
Not a fit: Patients without proprioceptive issues or those not affected by motor coordination disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for movement disorders related to proprioceptive dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding proprioception through genetic manipulation, indicating potential for success in this novel approach.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ESPINO, CYRRUS MAXWELL — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: ESPINO, CYRRUS MAXWELL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder, autism spectrum disorder, Autistic Disorder, autistic spectrum disorder