Understanding how a specific protein affects blood vessel inflammation after COVID-19
Official title: Kmt2a/MLL1 regulation of endothelial activation
Funded at University of Michigan at Ann Arbor · NIH-11105854 · Data updated 2026-11-12
This study is looking at how a protein called MLL1 affects inflammation in blood vessels after severe COVID-19, with the hope of finding new treatments for patients dealing with related complications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | June 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $616,880 |
| NIH project number | 5R01HL171135-02 |
| Project ID | NIH-11105854 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients who have experienced severe COVID-19 infections and are suffering from complications related to blood vessel inflammation.
✕Less likely to help
Patients who have not been infected with SARS-CoV-2 or those with mild COVID-19 symptoms may not benefit from this research.
What this research studies
This research investigates the role of a protein called MLL1 in the inflammation of blood vessels, known as endotheliitis, which can occur after severe COVID-19 infections. By studying human samples and animal models, the researchers aim to identify how MLL1 influences the expression of genes related to blood vessel function and clotting. The goal is to uncover specific mechanisms that could lead to targeted therapies for patients suffering from complications related to COVID-19. This work is crucial as current treatments are limited and often have significant side effects.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that specifically address the complications of COVID-19 related endotheliitis, improving patient outcomes.
How similar studies have gone: Other research has shown promise in targeting specific pathways involved in endothelial dysfunction, suggesting that this approach could be effective.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Obi, Andrea Tara — University of Michigan at Ann Arbor
- Study coordinator: Obi, Andrea Tara
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.