Understanding how a specific protein affects blood vessel health in heart disease
The Role of Adaptor Protein Disabled-2 in Maintaining Endothelial Cell Function in Atherosclerosis
This study is looking at how a protein called Disabled-2 helps keep the cells that line our blood vessels healthy, which is important for preventing heart problems like atherosclerosis, and it could lead to new treatments for heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10988255 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called Disabled-2 in maintaining the health of endothelial cells, which line blood vessels and are crucial for cardiovascular function. The study focuses on how dysfunction in these cells contributes to atherosclerosis, a condition characterized by plaque buildup in arteries. By using specialized mouse models, researchers aim to uncover the mechanisms by which Disabled-2 protects against endothelial dysfunction and atherogenesis, potentially leading to new therapeutic targets for heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for cardiovascular diseases, particularly those with atherosclerosis or related conditions.
Not a fit: Patients with non-cardiovascular conditions or those without any risk factors for atherosclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve endothelial function and reduce the risk of heart attacks and strokes.
How similar studies have performed: Previous research has shown promising results in understanding the role of various proteins in endothelial function, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Chen, Hong — Boston Children's Hospital
- Study coordinator: Chen, Hong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.