Understanding how a specific protein affects blood vessel health and diabetes
Official title: A Novel role of Endothelial Breakpoint Cluster Region Protein in Vascular Health and Disease
Funded at Ut Southwestern Medical Center · NIH-10999431 · Data updated 2026-11-12
This study is looking at how a protein called BCR in the cells that line your blood vessels helps keep your blood vessels healthy and may lower inflammation and blood sugar levels, which could be helpful for people dealing with heart issues and type 2 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $478,071 |
| NIH project number | 5R01HL168276-02 |
| Project ID | NIH-10999431 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with type 2 diabetes or those at risk for cardiovascular diseases.
✕Less likely to help
Patients who do not have any vascular health issues or diabetes may not benefit from this research.
What this research studies
This research investigates the role of the Breakpoint Cluster Region (BCR) protein in endothelial cells, which line blood vessels, and its influence on high-density lipoprotein (HDL) levels. The study aims to uncover how BCR contributes to reducing inflammation in blood vessels, promoting new blood vessel formation, and maintaining normal blood sugar levels. By using cultured endothelial cells and genetically modified mice, researchers will explore the mechanisms through which BCR mediates the protective effects of HDL against conditions like atherosclerosis and type 2 diabetes. This could lead to new insights into vascular health and diabetes management.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing cardiovascular diseases and managing diabetes.
How similar studies have gone: Previous research has shown promising results in understanding HDL's role in vascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Mineo, Chieko — Ut Southwestern Medical Center
- Study coordinator: Mineo, Chieko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.