Understanding how a specific protein affects blood cell formation and related diseases
Official title: Investigating the functional role of a degron in ASXL1 in hematopoiesis and disease
Funded at Harvard University · NIH-11061193 · Data updated 2026-11-12
This study is looking at how changes in a protein called ASXL1, which often has mutations in blood disorders, affect the way blood cells are made, with the hope of finding new ways to treat conditions like chronic myelomonocytic leukemia.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $35,118 |
| NIH project number | 5F31HL174076-02 |
| Project ID | NIH-11061193 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with myeloid malignancies or other blood disorders associated with ASXL1 mutations.
✕Less likely to help
Patients without ASXL1 mutations or those with unrelated blood disorders may not benefit from this research.
What this research studies
This research investigates the role of the ASXL1 protein, which is frequently mutated in blood disorders, particularly in myeloid malignancies. The study aims to understand how mutations in ASXL1 lead to abnormal blood cell formation and contribute to diseases like chronic myelomonocytic leukemia. By examining the mechanisms behind ASXL1 mutations and their effects on hematopoietic stem cells, the research seeks to uncover potential therapeutic targets. Patients may benefit from insights that could lead to improved treatments for blood-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients with blood disorders linked to ASXL1 mutations.
How similar studies have gone: Previous research has shown promising results in understanding the role of similar proteins in blood disorders, indicating potential for success in this area.
Where this research is happening
-
Harvard University
Cambridge, United States Active
Researchers
- Principal investigator: Shen, Simon P — Harvard University
- Study coordinator: Shen, Simon P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.