Understanding how a specific protein affects blood cell development
Investigation into the role of autophagy protease ATG4A in normal and impaired erythropoiesis
This study is looking at how a protein called ATG4A helps in the growth of red blood cells, especially in people with blood disorders like Myelodysplastic syndromes (MDS), to find new ways to improve blood cell production.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11014077 on NIH RePORTER |
What this research studies
This research investigates the role of the autophagy protease ATG4A in the development of red blood cells, particularly focusing on how it functions during normal and impaired blood cell formation. The study aims to understand the mechanisms by which ATG4A influences the growth and maturation of erythroid progenitors, especially in patients with conditions like Myelodysplastic syndromes (MDS) that affect blood production. By examining the effects of oxidative stress on ATG4A, the research seeks to uncover potential therapeutic targets for improving blood cell development in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with Myelodysplastic syndromes (MDS) or other blood disorders that affect red blood cell production.
Not a fit: Patients with conditions unrelated to blood cell production or those without any hematological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients with blood disorders, particularly those with impaired erythropoiesis.
How similar studies have performed: While the specific role of ATG4A in erythropoiesis is being explored here, similar research has shown promise in understanding autophagy's role in other blood-related conditions.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Stolla, Massiel Chavez — University of Washington
- Study coordinator: Stolla, Massiel Chavez
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.