Understanding how a specific protein affects blood-brain barrier functions
Official title: The role of ATP13A5 ATPase in determining blood-brain pericyte functions
Funded at University of Southern California · NIH-10814088 · Data updated 2026-11-12
This study is looking at a protein called ATP13A5 to see how it helps special cells in the brain that protect our brain's blood supply, which is important for keeping our brain healthy, especially for people with conditions like Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | September 19, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,438,887 |
| NIH project number | 1RF1NS135617-01 |
| Project ID | NIH-10814088 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with conditions unrelated to Alzheimer's disease or those who do not have any neurodegenerative disorders may not benefit from this research.
What this research studies
This research investigates the role of the ATP13A5 protein in the functioning of blood-brain pericytes, which are crucial for maintaining the integrity of the blood-brain barrier (BBB). By studying animal models, the research aims to uncover genetic markers and molecular mechanisms that differentiate the BBB from other blood vessels. This could lead to better understanding of how the BBB contributes to neurodegenerative diseases like Alzheimer's. Patients may benefit from insights that could improve drug delivery methods for treating these conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Alzheimer's disease and related dementias by enhancing drug delivery across the blood-brain barrier.
How similar studies have gone: Previous research has shown promise in understanding blood-brain barrier mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Zhao, Zhen — University of Southern California
- Study coordinator: Zhao, Zhen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.