Understanding how a specific protease affects the virulence of Staphylococcus aureus
Dissecting the Influence of a C-Terminal Processing Protease on S. aureus Pathogenesis
['FUNDING_R01'] · UNIVERSITY OF SOUTH FLORIDA · NIH-10799615
This study is looking at a specific protein in the Staphylococcus aureus bacteria to see how it helps the bacteria cause infections and how it interacts with our immune system, with the hope of finding new ways to treat these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTH FLORIDA (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-10799615 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protease called SaCtpA in the virulence of Staphylococcus aureus, a bacterium responsible for various infections. The study examines how this protease interacts with the immune system and affects the bacterium's ability to cause disease. By using animal models, researchers will assess the impact of SaCtpA on infection outcomes and explore its potential as a target for new treatments. The goal is to uncover the mechanisms by which this protease contributes to the bacterium's survival and pathogenicity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with infections caused by Staphylococcus aureus or those at high risk for such infections.
Not a fit: Patients with infections caused by other types of bacteria or those not infected may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating infections caused by Staphylococcus aureus.
How similar studies have performed: Previous studies have shown promising results in understanding similar proteases in other bacteria, indicating potential for success in this research.
Where this research is happening
TAMPA, UNITED STATES
- UNIVERSITY OF SOUTH FLORIDA — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHAW, LINDSEY NEIL — UNIVERSITY OF SOUTH FLORIDA
- Study coordinator: SHAW, LINDSEY NEIL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.