Understanding how a specific pathway affects egg quality and aging in women
A functional neddylation pathway underlies oocyte quality and aging
This study is looking at how a process called neddylation affects the quality of eggs in women, especially those over 35, to help understand why egg quality declines with age and find ways to improve reproductive health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10672284 on NIH RePORTER |
What this research studies
This research investigates the role of a process called neddylation in the quality of eggs (oocytes) and how it relates to aging in women. It focuses on understanding why egg quality declines as women age, particularly those over 35, who face higher risks of miscarriage and birth defects. By studying a specific enzyme involved in this process, the research aims to uncover mechanisms that could improve reproductive health and outcomes for women. The approach includes using genetically modified mice to explore the effects of neddylation on egg development and fertility.
Who could benefit from this research
Good fit: Ideal candidates for this research are women over the age of 35 who are considering pregnancy and may be at risk for complications related to egg quality.
Not a fit: Patients who are younger than 35 or those who are not planning to conceive may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving egg quality and fertility in older women, potentially reducing the risks of miscarriage and birth defects.
How similar studies have performed: While the specific focus on neddylation in oocyte quality is novel, related research has shown that understanding cellular processes can lead to significant advancements in reproductive health.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Pangas, Stephanie a. — Baylor College of Medicine
- Study coordinator: Pangas, Stephanie a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.