Understanding how a specific pathway affects DNA replication and repair
Investigating the roles of the H3.1-TSK/TONSL pathway during chromatin replication
This study is looking at a specific pathway in our cells that helps with copying DNA and fixing any mistakes, which is important for preventing diseases like cancer and neurodegenerative disorders, and it’s designed for anyone interested in understanding how our genes stay healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11100093 on NIH RePORTER |
What this research studies
This research investigates the H3.1-TSK/TONSL pathway, which plays a crucial role in chromatin replication and the transmission of genetic information. By examining how this pathway influences DNA repair and replication processes, the study aims to uncover mechanisms that could lead to genetic mutations associated with diseases like cancer and neurodegenerative disorders. The research employs advanced molecular biology techniques to analyze the interactions between histone variants and DNA repair proteins, providing insights into maintaining genomic stability.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic predispositions to cancer or neurodegenerative disorders, as well as those interested in the underlying mechanisms of these diseases.
Not a fit: Patients with conditions unrelated to genetic mutations or those not affected by cancer or neurodegenerative disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers and neurodegenerative disorders by enhancing our understanding of DNA replication and repair mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding the roles of epigenetic mechanisms in DNA repair, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Jacob, Yannick — Yale University
- Study coordinator: Jacob, Yannick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.