Understanding how a specific molecule affects cell movement
Official title: Investigating the regulation of PI(3,4)P2 in migrating cells
Funded at Amherst College · NIH-10582333 · Data updated 2026-11-12
This study is looking at how a special molecule helps cells move, which is important for healing wounds and understanding cancer spread, and it aims to find out how this molecule works with another protein to control cell movement, which could help improve treatments for different health issues.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Amherst College NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $99,177 |
| NIH project number | 3R15GM143733-01S1 |
| Project ID | NIH-10582333 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or conditions that involve abnormal cell migration.
✕Less likely to help
Patients with non-malignant conditions unrelated to cell migration may not benefit from this research.
What this research studies
This research investigates the role of a molecule called PI(3,4)P2 in the movement of cells, which is crucial for processes like wound healing and cancer metastasis. The study focuses on how this molecule interacts with another protein, Ras, to regulate cell migration. By using a model organism called Dictyostelium, the researchers aim to uncover the mechanisms that control cell movement and how these processes might be altered in diseases. The findings could lead to new insights into how to manipulate cell migration in various medical conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers and other diseases where cell migration plays a critical role.
How similar studies have gone: Previous research has shown that understanding cellular signaling pathways can lead to significant advancements in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
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Amherst College
Amherst, United States Active
Researchers
- Principal investigator: Edwards, Marc — Amherst College
- Study coordinator: Edwards, Marc
Related research
Other NIH-funded projects on the same topics.
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Understanding how resistance to common diseases affects the emergence of new diseases
This study looks at how different levels of disease resistance in plants and animals can affect the spread of new diseases when new germs come into play, and it aims to help us understand how to better manage and prevent these diseases in the future.
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Understanding how a specific molecule affects cell movement
This study is looking at how a special molecule helps cells move around, which is important for healing wounds and understanding cancer spread, and it could help us find new ways to control cell movement in different health issues.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.