Understanding how a specific mitochondrial protein affects heart development
Novel function of a mitochondria phosphatase in cardiac development
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10879134
This study is looking at a protein called PTPMT1 to see how it helps heart muscle cells grow and work properly, using a special mouse model to understand what happens when this protein is missing, which could help us learn more about heart problems that some babies are born with.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10879134 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a mitochondrial protein called PTPMT1 in the development of heart muscle cells. By creating a mouse model that lacks this protein specifically in heart cells, researchers are studying how its absence affects heart structure and function. The study focuses on understanding the molecular pathways involved in heart development and how disruptions can lead to congenital heart disease. Through advanced techniques like RNA sequencing, the research aims to uncover the critical functions of PTPMT1 during cardiac development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital heart disease or those at risk due to genetic factors affecting mitochondrial function.
Not a fit: Patients with acquired heart conditions unrelated to genetic or mitochondrial factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into congenital heart disease and potential therapeutic targets for improving heart health.
How similar studies have performed: Other research has shown success in understanding mitochondrial functions in heart development, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, JU — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: CHEN, JU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.