Understanding how a specific microRNA affects immune cell development and function
The role of miR-142 in regulatory T cell Development and function
This study is looking at how a tiny molecule called microRNA-142 affects the growth and job of special immune cells that help keep our bodies balanced and prevent diseases like autoimmune disorders and some cancers, with hopes of finding new treatments for these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-10906106 on NIH RePORTER |
What this research studies
This research investigates the role of microRNA-142 in the development and function of regulatory T cells, which are crucial for maintaining immune balance and preventing autoimmune diseases. By using genetic knockout mouse models, the study aims to uncover how miR-142 influences Treg cell differentiation and activity. The findings could lead to new immunotherapies targeting Treg cell-related diseases, including certain cancers and autoimmune disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or cancers where Treg cell function is compromised.
Not a fit: Patients with conditions unrelated to Treg cell dysfunction or those not affected by autoimmune diseases or cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for autoimmune diseases and improve cancer immunotherapy strategies.
How similar studies have performed: Previous research has shown promising results in understanding the role of microRNAs in immune cell regulation, suggesting that this approach could yield significant insights.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Boldin, Mark P — Beckman Research Institute/city of Hope
- Study coordinator: Boldin, Mark P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.