Understanding how a specific microRNA affects brain development and diseases like Alzheimer's
Defining the cell type-specific role of miR-9-2 in telencephalon development
This study is looking at a tiny molecule called miR-9-2 to see how it affects brain development and could be linked to diseases like Alzheimer's, using mice to understand what happens when this molecule is missing.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10909322 on NIH RePORTER |
What this research studies
This research investigates the role of the microRNA miR-9-2 in the development of the brain and its implications for neurological diseases such as Alzheimer's. Using mouse models, the study examines how the absence of miR-9-2 leads to brain malformations and explores the gene networks it regulates. By employing advanced techniques like transcriptomic and genomic analysis, the research aims to identify the genes and cellular processes influenced by miR-9-2, which could provide insights into disease mechanisms and potential treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Alzheimer's disease or related neurological disorders.
Not a fit: Patients with non-neurological conditions or those not affected by Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic factors involved in Alzheimer's disease, potentially paving the way for new therapeutic strategies.
How similar studies have performed: Previous research has shown that understanding gene regulatory networks in brain development can lead to significant advancements in treating neurological diseases, indicating a promising avenue for this study.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Fregoso, Santiago P — Seattle Children's Hospital
- Study coordinator: Fregoso, Santiago P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.