Understanding how a specific lipid affects the replication of Ebola and Lassa viruses
Defining the role of phosphatidylserine in hemorrhagic fever virus replication
['FUNDING_R01'] · UNIVERSITY OF GEORGIA · NIH-10570909
This study is looking at how a fat called phosphatidylserine helps Ebola and Lassa viruses infect human cells, which could lead to new treatments for these illnesses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF GEORGIA (nih funded) |
| Locations | 1 site (ATHENS, UNITED STATES) |
| Trial ID | NIH-10570909 on ClinicalTrials.gov |
What this research studies
This research investigates the role of phosphatidylserine (PS), a lipid found in cell membranes, in the replication of Ebola and Lassa viruses. By studying human cell lines that lack certain proteins responsible for flipping PS to the outer membrane, researchers aim to understand how these viruses utilize PS to infect cells. The project employs advanced biological assays to explore the mechanisms of viral entry and replication, which could lead to new antiviral strategies. Patients may benefit from insights gained in this research that could inform the development of effective treatments for these viral infections.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals at risk of Ebola or Lassa virus infections, particularly in endemic regions.
Not a fit: Patients with other viral infections not related to Ebola or Lassa viruses may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral therapies for Ebola and Lassa virus infections.
How similar studies have performed: Other research has shown success in understanding viral mechanisms of infection, but the specific role of phosphatidylserine in this context is still being explored.
Where this research is happening
ATHENS, UNITED STATES
- UNIVERSITY OF GEORGIA — ATHENS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRINDLEY, MELINDA ANN — UNIVERSITY OF GEORGIA
- Study coordinator: BRINDLEY, MELINDA ANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.