Understanding how a specific lipid affects the movement of a stomach bacteria.
Role of cardiolipin in Helicobacter pylori flagellar biogenesis
This study is looking at how a specific fat in bacteria helps Helicobacter pylori move around and live in the stomach, which could lead to new ways to treat people who have infections caused by this bacteria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project ID | NIH-10550216 on NIH RePORTER |
What this research studies
This research investigates the role of cardiolipin, a type of lipid, in the formation of flagella, which are tail-like structures that allow Helicobacter pylori to move. The study focuses on how this lipid contributes to the bacteria's ability to colonize the stomach, which is crucial for its survival and pathogenicity. By examining the genetic and biochemical pathways involved in flagellar biogenesis, the research aims to uncover new insights into how this bacteria interacts with its host. Patients with conditions related to H. pylori infection may benefit from the findings, as they could lead to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals suffering from peptic ulcers, chronic gastritis, or those at risk for gastric cancer due to H. pylori infection.
Not a fit: Patients who do not have H. pylori infections or related gastrointestinal conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for peptic ulcers and gastric cancer caused by H. pylori infections.
How similar studies have performed: While the specific role of cardiolipin in H. pylori flagellar biogenesis is a novel approach, similar studies on bacterial motility and pathogenicity have shown promising results in the past.
Where this research is happening
Athens, United States
- University of Georgia — Athens, United States (Active)
Researchers
- Principal investigator: Hoover, Timothy Randall — University of Georgia
- Study coordinator: Hoover, Timothy Randall
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.