Understanding how a specific ion channel affects recovery after spinal cord injury
The Function and Mechanisms of Voltage-Gated Proton Channel Hv1 in Spinal Cord Injury
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10878945
This study is looking at how a specific channel in brain cells, called Hv1, affects inflammation in the spinal cord after an injury, with the hope of finding new ways to help people recover better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10878945 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the voltage-gated proton channel Hv1 in the process of neuroinflammation following spinal cord injury (SCI). By examining how this ion channel influences the behavior of microglia and astrocytes, the study aims to uncover the cellular and molecular mechanisms that contribute to recovery after SCI. The researchers will utilize advanced techniques and genetically modified mice to explore the signaling pathways involved, which could lead to the development of new therapeutic strategies for improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a spinal cord injury and are seeking potential new therapies for recovery.
Not a fit: Patients with spinal cord injuries who are not experiencing neuroinflammation or those with chronic conditions unrelated to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that enhance recovery and improve neurological function in patients with spinal cord injuries.
How similar studies have performed: While the specific role of Hv1 in spinal cord injury is still being explored, similar research on ion channels and neuroinflammation has shown promise in other contexts.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WU, JUNFANG — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: WU, JUNFANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.