Understanding how a specific ion channel affects brain cell function and neurodegenerative diseases
Regulation of lysosomal potassium channels
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10802754
This study is looking at a special channel in our cells that helps with digestion and recycling, to see how it might affect diseases like Parkinson's, and it could help us understand more about aging and brain health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10802754 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the TMEM175 ion channel in lysosomal function, which is crucial for cellular processes like digestion and recycling. By studying this channel, researchers aim to uncover its impact on neurodegenerative diseases such as Parkinson's disease. The approach includes advanced techniques like organelle electrophysiology and functional studies in both mice and human cells. The findings could provide insights into how lysosomal dysfunction contributes to aging and neurodegeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative diseases, particularly those with a family history of conditions like Parkinson's disease.
Not a fit: Patients with non-neurodegenerative conditions or those without any genetic predisposition to related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in understanding lysosomal function and its implications in neurodegenerative diseases, suggesting that this approach has the potential for significant breakthroughs.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REN, DEJIAN — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: REN, DEJIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.