Understanding how a specific immune signaling pathway helps fight Leishmania major infections
Implicating a previously unknown Dectin1-RIPK2-CARD9 signaling in providing resistance against Leishmania major infection
This study is looking at how certain proteins in our immune system help fight off a skin infection caused by a parasite called Leishmania major, and it aims to find new ways to boost our body's defenses against this infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11042180 on NIH RePORTER |
What this research studies
This research investigates the role of a signaling pathway involving Dectin1, RIPK2, and CARD9 in the immune response against Leishmania major, a parasite that causes skin infections. The study aims to uncover how these proteins work together to enhance the body's ability to detect and respond to this infection. By using animal models, the researchers will explore the cellular and molecular mechanisms that contribute to resistance against the parasite, which could lead to new therapeutic strategies. The findings may provide insights into how similar pathways can be targeted to improve immune responses in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with Leishmania major infections or are at high risk of contracting the disease.
Not a fit: Patients who do not have Leishmania major infections or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response against Leishmania major infections, potentially reducing the burden of this disease.
How similar studies have performed: Other research has shown success in understanding immune signaling pathways in relation to various infections, suggesting that this approach may yield valuable insights.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Gurung, Prajwal — University of Iowa
- Study coordinator: Gurung, Prajwal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.