Understanding how a specific immune cell protein contributes to leukemia
Role of LAM-specific TREM1 in leukemogenesis
This project explores how a protein in certain immune cells helps leukemia grow, hoping to find new ways to stop it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11166422 on NIH RePORTER |
What this research studies
Cancer often grows with the help of surrounding cells, and in leukemia, special immune cells called leukemia-associated macrophages (LAMs) play a role. This project focuses on a protein called TREM1 found in these LAMs, which seems to help leukemia progress. Researchers are using advanced mouse models to understand exactly how TREM1 works within these immune cells to promote leukemia growth. By uncovering these detailed mechanisms, we hope to identify new targets for future leukemia treatments.
Who could benefit from this research
Good fit: This foundational work could eventually benefit patients with acute myeloid leukemia (AML) by identifying new therapeutic targets.
Not a fit: Patients whose leukemia does not involve the specific TREM1 pathway in macrophages may not directly benefit from this particular approach.
Why it matters
Potential benefit: If successful, this work could lead to new treatment strategies for acute myeloid leukemia by targeting specific immune cells.
How similar studies have performed: While TREM1 has been linked to other cancers, its specific role in the leukemia microenvironment is still being explored in this novel approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Du, Wei — University of Pittsburgh at Pittsburgh
- Study coordinator: Du, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.