Understanding how a specific histone variant affects cancer growth
Characterization of short H2A Oncohistones in Cancer
This study is looking at a special protein called H2A.B in cancer cells to see how it might change the way DNA is organized, which could help us understand new ways that cancer develops and find new treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10901876 on NIH RePORTER |
What this research studies
This research investigates the role of a histone variant, H2A.B, in destabilizing nucleosomes in various cancers. By examining how this variant is expressed in cancer cells, the study aims to uncover new mechanisms of oncogenesis that do not rely on traditional mutations. The researchers utilize advanced techniques such as CRISPR and bioinformatics to analyze cancer cell lines and identify patterns of alternative splicing associated with H2A.B expression. This work could lead to new insights into cancer biology and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with diffuse large B-cell lymphoma or other cancers where H2A.B expression has been identified.
Not a fit: Patients with cancers that do not express the H2A.B variant or those with non-malignant conditions are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting specific cancers driven by the H2A.B histone variant.
How similar studies have performed: Other research has shown promising results in understanding the role of histone variants in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Sarthy, Jay — Seattle Children's Hospital
- Study coordinator: Sarthy, Jay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.