Understanding how a specific heart valve condition affects blood flow and calcification
Bicuspid Aortic Valve Biomechanics and Calcification
This study is looking at how a heart valve problem called calcific aortic stenosis affects people of all ages, especially those with a special type of valve, to better understand how it develops and impacts heart health over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11045737 on NIH RePORTER |
What this research studies
This research investigates calcific aortic stenosis (CAS), a common heart valve disorder that affects both adolescents and older adults. It focuses on the biomechanics of the bicuspid aortic valve, which can lead to increased stress and early calcification compared to normal valves. By examining the mechanisms behind these changes, the research aims to improve understanding of how this condition progresses and impacts patients. The study will utilize advanced imaging and biomechanical analysis to gather data on valve function and structure over time.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with a bicuspid aortic valve, particularly adolescents and older adults experiencing symptoms of aortic stenosis.
Not a fit: Patients with normal tri-leaflet aortic valves or those without any aortic valve disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with aortic valve disorders, potentially delaying or preventing the need for surgical interventions.
How similar studies have performed: Previous research has shown promising results in understanding the biomechanics of heart valves, suggesting that this approach could yield valuable insights into aortic valve disorders.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Lincoln, Joy — Medical College of Wisconsin
- Study coordinator: Lincoln, Joy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.