Understanding how a specific heart valve condition affects blood flow and calcification
Official title: Bicuspid Aortic Valve Biomechanics and Calcification
Funded at Medical College of Wisconsin · NIH-11045737 · Data updated 2026-11-12
This study is looking at how a heart valve problem called calcific aortic stenosis affects people of all ages, especially those with a special type of valve, to better understand how it develops and impacts heart health over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | March 1, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $435,779 |
| NIH project number | 5R01HL172851-02 |
| Project ID | NIH-11045737 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with a bicuspid aortic valve, particularly adolescents and older adults experiencing symptoms of aortic stenosis.
✕Less likely to help
Patients with normal tri-leaflet aortic valves or those without any aortic valve disorders may not benefit from this research.
What this research studies
This research investigates calcific aortic stenosis (CAS), a common heart valve disorder that affects both adolescents and older adults. It focuses on the biomechanics of the bicuspid aortic valve, which can lead to increased stress and early calcification compared to normal valves. By examining the mechanisms behind these changes, the research aims to improve understanding of how this condition progresses and impacts patients. The study will utilize advanced imaging and biomechanical analysis to gather data on valve function and structure over time.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with aortic valve disorders, potentially delaying or preventing the need for surgical interventions.
How similar studies have gone: Previous research has shown promising results in understanding the biomechanics of heart valves, suggesting that this approach could yield valuable insights into aortic valve disorders.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Lincoln, Joy — Medical College of Wisconsin
- Study coordinator: Lincoln, Joy
Related research
Other NIH-funded projects on the same topics.
-
Finding a cure for sickle cell disease
The Cure Sickle Cell Initiative is bringing together patients, families, and caregivers to work together on finding a cure for sickle cell disease using safe genetic therapies, with the goal of improving lives and speeding up the development of new treatments.
-
A portable device to measure radiation dose and exposure uniformity after a large radiation event
A field-ready, nail-based device uses advanced spectroscopy and smart software to quickly estimate how much radiation a person has received and how evenly they were exposed, within minutes.
-
Ethics of Engaging Patient Groups in Drug Development for Rare Diseases
This grant asks how patient and family groups can ethically help shape rare-disease drug development from idea to market, with input from patients, families, doctors, and researchers.
-
Renovation of the Biophysics Resources at MCW
This grant funds upgrading a core biophysics facility at the Medical College of Wisconsin to support advanced research in human biology.
-
Cure Sickle Cell: Advancing Gene Therapies for Sickle Cell Disease
A national initiative to move safer genetic therapies for sickle cell disease forward with patient, caregiver, and advocate involvement.
-
Health insurance transitions for older adults with HIV on Medicare
Older adults with HIV face complex Medicare coverage that can affect access to HIV treatment and care.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.