Understanding how a specific heart fat affects energy production in heart cells
Official title: Molecular basis to regulate the cardiac-specific form of mitochondrial phospholipid cardiolipin
Funded at Johns Hopkins University · NIH-10807267 · Data updated 2026-11-12
This study is looking at how a special fat called cardiolipin helps your heart produce energy and stay healthy, especially in people with heart conditions, to find out how changes in cardiolipin might lead to heart problems.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $107,298 |
| NIH project number | 1K99HL168075-01A1 |
| Project ID | NIH-10807267 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cardiac disorders, particularly those experiencing cardiomyopathy or other forms of heart failure.
✕Less likely to help
Patients with non-cardiac related health issues or those without any cardiac conditions may not receive benefits from this research.
What this research studies
This research investigates the role of cardiolipin, a crucial phospholipid found in the mitochondria of heart cells, in energy production necessary for proper cardiac function. The study aims to clarify how different forms of cardiolipin, particularly those enriched with linoleic acid, are regulated in the heart and how this regulation impacts heart health. By exploring various theories about cardiolipin acylation, the research seeks to uncover the mechanisms that may lead to cardiac diseases when these processes go awry. Patients with cardiac conditions may benefit from insights gained into how cardiolipin metabolism affects heart function.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cardiac diseases linked to mitochondrial dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial function and cardiolipin's role in heart health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Senoo, Nanami — Johns Hopkins University
- Study coordinator: Senoo, Nanami
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.