Understanding how a specific growth factor helps heart healing after a heart attack
Investigating the role of myeloid-derived growth factor in opposing neutrophil mechanical activation to regulate cardiac healing in the context of myocardial infarction
This study is looking at how a special protein called MYDGF helps the heart heal after a heart attack by understanding how certain immune cells, called neutrophils, react to signals during recovery, which could lead to new ways to help your heart recover better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10902672 on NIH RePORTER |
What this research studies
This research investigates the role of myeloid-derived growth factor (MYDGF) in the healing process of the heart following a myocardial infarction (heart attack). It focuses on how neutrophils, a type of immune cell, respond to mechanical and chemical signals during recovery. By using advanced microfluidic technology and genetically modified neutrophils, the study aims to uncover the mechanisms by which MYDGF influences neutrophil behavior and cardiac repair. This could lead to new therapeutic strategies for improving heart recovery after a heart attack.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently experienced a myocardial infarction and are at risk for complications such as heart failure or stroke.
Not a fit: Patients who have not experienced a myocardial infarction or those with chronic heart conditions unrelated to acute cardiac events may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance heart healing and reduce complications after a heart attack.
How similar studies have performed: Previous research has shown promise in understanding the role of immune cells in cardiac healing, but this specific approach using MYDGF is relatively novel.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Schrope, Jon — University of Wisconsin-Madison
- Study coordinator: Schrope, Jon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.