Understanding how a specific genetic variant protects against Alzheimer's Disease
Official title: Determining the mechanisms of the protective APOE3ch variant on Alzheimer's Disease pathologies
Funded at University of California-Irvine · NIH-10928115 · Data updated 2026-11-12
This study is looking at a special genetic variant that might help protect against Alzheimer's disease, and it hopes to find out how this variant affects the harmful changes in the brain that lead to the disease, which could help develop new treatments for people with Alzheimer's or those at risk.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | August 10, 2023 |
| Project end | August 9, 2025 |
| Funding year | 2024 |
| Award (this year) | $45,458 |
| NIH project number | 5F31AG084190-02 |
| Project ID | NIH-10928115 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with Alzheimer's Disease or those at high risk due to genetic factors.
✕Less likely to help
Patients with non-Alzheimer's forms of dementia or cognitive decline unrelated to amyloid or tau pathology may not benefit from this research.
What this research studies
This research investigates the protective effects of a rare genetic variant, APOE3ch, on Alzheimer's Disease (AD) pathologies. It aims to uncover the mechanisms by which this variant influences the development of amyloid plaques and tau tangles, which are key features of AD. By studying the interactions between these pathological hallmarks, the research seeks to identify potential new therapeutic targets. Patients with Alzheimer's or at risk for the disease may benefit from insights gained through this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's Disease.
How similar studies have gone: Previous research has shown promise in understanding genetic factors influencing Alzheimer's Disease, but the specific approach of this study is novel.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Tran, Kristine Minh — University of California-Irvine
- Study coordinator: Tran, Kristine Minh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.