Understanding how a specific genetic variant protects against Alzheimer's Disease
Determining the mechanisms of the protective APOE3ch variant on Alzheimer's Disease pathologies
This study is looking at a special genetic variant that might help protect against Alzheimer's disease, and it hopes to find out how this variant affects the harmful changes in the brain that lead to the disease, which could help develop new treatments for people with Alzheimer's or those at risk.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10928115 on NIH RePORTER |
What this research studies
This research investigates the protective effects of a rare genetic variant, APOE3ch, on Alzheimer's Disease (AD) pathologies. It aims to uncover the mechanisms by which this variant influences the development of amyloid plaques and tau tangles, which are key features of AD. By studying the interactions between these pathological hallmarks, the research seeks to identify potential new therapeutic targets. Patients with Alzheimer's or at risk for the disease may benefit from insights gained through this research.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Alzheimer's Disease or those at high risk due to genetic factors.
Not a fit: Patients with non-Alzheimer's forms of dementia or cognitive decline unrelated to amyloid or tau pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's Disease.
How similar studies have performed: Previous research has shown promise in understanding genetic factors influencing Alzheimer's Disease, but the specific approach of this study is novel.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Tran, Kristine Minh — University of California-Irvine
- Study coordinator: Tran, Kristine Minh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.