Understanding how a specific genetic deletion affects reward responses in the brain.
Defining the molecular impact of 16p11.2 deletion on reward response in striatal dopamine receptor D1-expressing neurons
This study is looking at how a specific genetic change affects brain cells that help us feel rewards, especially in people with conditions like Autism and ADHD, using mice to learn more about how these changes might help us find better ways to support those individuals.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10875275 on NIH RePORTER |
What this research studies
This research investigates the impact of a genetic deletion on brain cells that are crucial for processing rewards, particularly in individuals with neurodevelopmental disorders like Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder. By using a mouse model that mimics the human condition, the study aims to explore how these brain cells, known as dopamine receptor D1-expressing neurons, behave differently when the genetic deletion is present. The researchers will analyze the cellular and molecular mechanisms that underlie these changes, which could lead to better understanding and potential interventions for these disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Autism Spectrum Disorder or Attention Deficit Hyperactivity Disorder, particularly those with a known genetic deletion in the 16p11.2 region.
Not a fit: Patients without neurodevelopmental disorders or those whose conditions are unrelated to the 16p11.2 deletion may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapeutic strategies for treating neurodevelopmental disorders.
How similar studies have performed: Previous research has successfully utilized similar genetic models to study neurodevelopmental disorders, indicating a promising avenue for understanding these conditions.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Kelvington, Benjamin — University of Iowa
- Study coordinator: Kelvington, Benjamin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.