Understanding how a specific gene protects adrenal gland cells from dying.
Deciphering the protective effect of the transient marker gene, Dhcr24, in the adrenal gland inner cortex.
This study is looking at how a specific gene called Dhcr24 helps protect older cells in the adrenal gland from dying, and it’s for anyone interested in understanding how our bodies age and how hormones like thyroid hormone might play a role in keeping our cells healthy.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Auburn University at Auburn NIH-funded |
| Lab location | 1 site (Auburn, UNITED STATES) |
| Project ID | NIH-10581620 on NIH RePORTER |
What this research studies
This research investigates the role of the Dhcr24 gene in the adrenal gland's inner cortex, particularly how it may protect aged cells from apoptosis, or programmed cell death. The researchers will use advanced techniques, including next-generation sequencing, to analyze the effects of thyroid hormone on Dhcr24 expression and its subsequent impact on cell survival. By studying genetically modified mice, they aim to uncover the pathways and genes influenced by Dhcr24, which could lead to new insights into cell aging and survival mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting the adrenal gland, particularly those related to aging or adrenal tumors.
Not a fit: Patients with non-adrenal related conditions or those who are not experiencing issues with aging or adrenal function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions related to adrenal gland dysfunction and aging.
How similar studies have performed: While the specific approach of studying Dhcr24 in the adrenal gland is novel, similar research has shown promise in understanding gene roles in cell survival and aging.
Where this research is happening
Auburn, UNITED STATES
- Auburn University at Auburn — Auburn, United States (Active)
Researchers
- Principal investigator: Huang, Chen-Che Jeff — Auburn University at Auburn
- Study coordinator: Huang, Chen-Che Jeff
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.