Understanding how a specific gene mutation affects antibody production in patients.
A somatic hypermutation defective UNG mutant in antibody deficiency through destabilization of RPA interaction.
This study is looking at how a specific gene mutation in B cells affects the production of important antibodies in people with hyper IgM syndrome, which causes frequent infections, to find ways to help improve their antibody levels.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11101127 on NIH RePORTER |
What this research studies
This research investigates the role of a gene mutation in B cells that is crucial for producing high-affinity antibodies. It focuses on patients with hyper IgM syndrome, a condition that leads to frequent infections due to low antibody levels. By studying how the mutation affects the interaction between proteins involved in DNA repair, the research aims to uncover mechanisms that could improve antibody production. The approach includes analyzing cell line models to observe the effects of different mutations on antibody generation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hyper IgM syndrome or related antibody deficiencies.
Not a fit: Patients without antibody production issues or those not diagnosed with hyper IgM syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance antibody production in patients with immunodeficiencies.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of antibody production, making this approach a continuation of established findings.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Mcbride, Kevin Michael — University of Tx Md Anderson Can Ctr
- Study coordinator: Mcbride, Kevin Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.