Understanding how a specific gene mutation affects antibody production in patients.
Official title: A somatic hypermutation defective UNG mutant in antibody deficiency through destabilization of RPA interaction.
Funded at University of Tx Md Anderson Can Ctr · NIH-11101127 · Data updated 2026-11-12
This study is looking at how a specific gene mutation in B cells affects the production of important antibodies in people with hyper IgM syndrome, which causes frequent infections, to find ways to help improve their antibody levels.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $81,000 |
| NIH project number | 5R03AI175719-02 |
| Project ID | NIH-11101127 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with hyper IgM syndrome or related antibody deficiencies.
✕Less likely to help
Patients without antibody production issues or those not diagnosed with hyper IgM syndrome may not benefit from this research.
What this research studies
This research investigates the role of a gene mutation in B cells that is crucial for producing high-affinity antibodies. It focuses on patients with hyper IgM syndrome, a condition that leads to frequent infections due to low antibody levels. By studying how the mutation affects the interaction between proteins involved in DNA repair, the research aims to uncover mechanisms that could improve antibody production. The approach includes analyzing cell line models to observe the effects of different mutations on antibody generation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance antibody production in patients with immunodeficiencies.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of antibody production, making this approach a continuation of established findings.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Mcbride, Kevin Michael — University of Tx Md Anderson Can Ctr
- Study coordinator: Mcbride, Kevin Michael
Related research
Other NIH-funded projects on the same topics.
-
HIV-related cervical cancer screening and care in LMICs (AVANÇO HAMRC)
A multi-country effort to build sustainable research infrastructure and low-cost cervical cancer screening and treatment methods for women living with HIV in Brazil and Mozambique.
-
HIV-associated cervical cancer care infrastructure in LMICs
A program to build sustainable research infrastructure and bring low-cost cervical cancer screening, diagnosis, and treatment to women with HIV in Brazil and Mozambique.
-
HIV-associated cervical cancer screening and care network in LMICs
A multinational program aims to build affordable, practical cervical cancer screening, diagnosis, and treatment methods for women living with HIV in Brazil and Mozambique.
-
Mapping HIV-like SIV Reservoirs in the Brain with Advanced PET Imaging
This project develops brain-targeted imaging probes to map SIV reservoirs in the central nervous system of infected macaques, aiming to improve our understanding of how HIV-like viruses hide in the brain.
-
Telomerase in Alzheimer’s Disease: how aging biology could influence memory and brain health
Researchers are exploring a new brain-aging mechanism linked to telomerase, with potential to slow or modify Alzheimer’s disease in people and improve cognitive function.
-
Germline clues to skin-related immune side effects from cancer immunotherapy
This grant looks for genetic clues in people treated with immune checkpoint inhibitors to understand why some develop skin-related immune side effects.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.