Understanding how a specific gene influences the development of salivary glands
Official title: Genetic and molecular mechanisms of Xbp-1 mediated salivary gland development and differentiation
Funded at State University of New York at Buffalo · NIH-10849654 · Data updated 2026-11-12
This study is looking at how a specific gene called Xbp-1 helps shape the development of salivary glands, which is important for keeping them healthy, and it hopes to find ways to help these glands heal after injury or illness.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $34,650 |
| NIH project number | 5F31DE032901-02 |
| Project ID | NIH-10849654 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting salivary gland function or those interested in regenerative medicine.
✕Less likely to help
Patients without any salivary gland issues or those not interested in regenerative therapies may not benefit from this research.
What this research studies
This research investigates the role of the Xbp-1 gene in the development and differentiation of salivary glands. It aims to uncover the molecular mechanisms that regulate cell fate decisions during the formation of these glands, which is crucial for maintaining normal tissue function. By studying how Xbp-1 affects the identity and function of salivary gland cells, the research seeks to identify pathways that could be targeted for tissue regeneration after injury or disease. The approach includes analyzing gene expression and cellular behavior in both embryonic and adult salivary glands.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for regenerating salivary gland tissue in patients with damage or disease.
How similar studies have gone: While the specific role of Xbp-1 in salivary gland development is less explored, similar research on gene regulation in tissue regeneration has shown promising results.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Wrynn, Theresa — State University of New York at Buffalo
- Study coordinator: Wrynn, Theresa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.