Understanding how a specific gene helps regulate immune tolerance
Defining the Role of Aire in eTACs and its Contribution to Peripheral Immune Tolerance
This study is looking at how a gene called Aire helps certain immune cells in the spleen and lymph nodes work better to prevent autoimmune diseases, which could lead to new treatments for people with these conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10871694 on NIH RePORTER |
What this research studies
This research investigates the role of the Aire gene in specific immune cells known as extrathymic Aire-expressing cells (eTACs), which are found in the spleen and lymph nodes. By examining how Aire influences these cells, the research aims to uncover mechanisms that help prevent autoimmune diseases by promoting tolerance to self-antigens. The approach involves analyzing the genetic and functional characteristics of eTACs to determine their contribution to immune regulation. Patients may benefit from insights gained about immune tolerance that could lead to new treatments for autoimmune conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or those at risk of developing such conditions.
Not a fit: Patients with non-autoimmune conditions or those not affected by immune tolerance issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating autoimmune diseases.
How similar studies have performed: Previous research has shown promising results in understanding immune tolerance mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Wang, Jiaxi — University of California, San Francisco
- Study coordinator: Wang, Jiaxi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.